From Mendel to the Human Genome Project

Personal genomes in progress: from the Human Genome Project to the Personal Genome Project

The cost of a diploid human genome sequence has dropped from about $70M to $2000 since 2007--even as the standards for redundancy have increased from 7x to 40x in order to improve call rates. Coupled with the low return on investment for common single-nucleotide polylmorphisms, this has caused a significant rise in interest in correlating genome sequences with comprehensive environmental and tr...

The Human Genome Project.

Dear readers, The last few decades have seen a number of exciting developments in genetics. First, Watson and Crick broke the genetic code; since then, tech-nologic and methodologic breakthroughs have permitted the study and direct manipulation of our DNA. Now there is an international ground swell to map and sequence the human genome. The Bush administration had originally requested $128 milli...

The Human Genome Project.

The Human Genome Project

genetic mapping; DNA; applied research; molecular genetics T Human Genome Project is an international research project whose primary mission is to decipher the chemical sequence of the complete human genetic material (i.e., the entire genome), identify all 50,000 to 100,000 genes contained within the genome, and provide research tools to analyze all this genetic information. This ambitious proj...

The Human Genome Project

In January, Harold Varmus will begin the next stage in an unusual career. He’s gone from English literature to medicine to bench science to Washington science bureaucrat, and now he becomes the well-paid (some would say extremely well-paid) president of a private, not-for-profit treatment and research facility, the Memorial Sloan Kettering Cancer Center in New York. He’s succeeded in everything...